Frame your focal photo on your layout somehow.
Don't from your other pictures (if you include them that is, it can totally be a one photo LO).
Here's a technique you could try if you want...
stamped frameOr you can do like I did on this page...
Add a frame digitally and then cut out the whole thing frame and all...(this one is by House of 3)
Or think of your own way to frame your photo!